Layer Health Named to the 2025 CB Insights’ List of the 50 Most Promising Digital Health Startups

Layer Health recognized for achievements in chart review and abstraction 

BOSTON, October 20, 2025 – CB Insights today named Layer Health to its seventh annual Digital Health 50, showcasing the 50 most promising private digital health companies in the world.

“The 2025 Digital Health 50 winners are high-momentum companies poised to define the next era of healthcare,” said Ellen Knapp, Principal Analyst at CB Insights. “This year’s cohort is advancing the shift from reactive to proactive care, developing AI solutions tailored to healthcare's unique regulatory environment, and addressing critical sector-wide challenges from care access to provider burnout and workforce shortages.”

"We are honored to be recognized for the team's impactful work solving one of healthcare's biggest challenges - chart abstraction", said Layer Health CEO, David Sontag. "From making clinical registry submission frictionless to creating intelligent clinical pathways, we are excited to continue helping health systems deliver better care for patients in an efficient, scalable manner."

The list primarily includes early- and mid-stage startups driving innovation across digital health. Our research team picked winning companies based on CB Insights datasets, including deal activity, industry partnerships, team strength, investor strength, employee headcount, and proprietary Commercial Maturity and Mosaic scores. We also dug into Analyst Briefings submitted directly to us by startups.

Layer Health's AI-powered platform helps to automate the labor-intensive process of medical chart review, supporting critical functions such as quality reporting, registry submission, and a growing range of operational and clinical workflows. Leveraging advanced large language models trained on rich, longitudinal patient data, the platform can interpret both structured and unstructured clinical information with high accuracy.

Quick facts on the 2025 Digital Health 50:

• The 50 winners span categories such as care delivery, revenue cycle management, drug discovery & development, and diagnostics.

• This year's cohort is deploying AI across a wide variety of use cases, with notable adoption of agentic AI, voice AI, and automated provider workflows.

• Collectively raised $2B in equity funding in 2025 YTD (as of 10/14/2025).

• 52% are early-stage companies (seed/angel or Series A funding).

• Established 140+ business relationships since 2024 with industry leaders including Cleveland Clinic, IBM, and Novartis.

About CB Insights

CB Insights is the leader in predictive intelligence on private companies. It delivers instant insights that help you source and analyze private companies, focus on the right markets, and stay ahead of competitors. Our AI agents are powerful because they translate signals into the exact outputs your teams need to move first — defensible, sourced, and board-ready. To learn more, please visit www.cbinsights.com. 

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 About Layer Health

Layer Health is a cutting-edge healthcare AI company that harnesses the power of large language models (LLMs) to transform data abstraction and unlock high-value insights from structured and unstructured EHR data. Founded by AI and clinical leaders from some of the most prestigious academic and healthcare organizations, the company is building a next-generation AI platform to help its partners improve clinical care, streamline operations and financial performance. The company is backed by leading investors, including Define Ventures, GV, Flare Capital Partners, MultiCare and others. For more information, visit www.layerhealth.com.